- 职 业
- 籍 贯
董欣年教授籍贯是浙江宁波，出身于学术世家。父亲是有“一代经济学泰斗”之称的董辅礽 。母亲刘蔼年，是中国著名眼科医生、教授。一家都是武汉大学校友。其中董辅礽1946年毕业于国立武汉大学，后来成为武大教授和经济系主任。母亲刘氏 1949年毕业于武大，曾是解放军海军总医院眼科主任。有弟董欣中，美国约翰霍普金斯大学神经生物学教授。丈夫王小凡，是董欣年在武大的同学，与董欣年同为杜克大学教授，任教于药理系。
Cell and Molecular Biology
Research Categories: Plant-Microbe interactions
Current projects: (1) Functional analysis of NPR1, a positive regulator of SAR, (2) Functional analysis of SNI1, a negative regulator of SAR, (3) Study of cross-talks between different defense pathways, (4) Study of programmed cell death in plant defense, (5) Expression profiling of plant defense responses, (6) Study of protein secretory pathway in plant defense, (7) Characterization of antifungal proteins in seeds
Research Description: Using Arabidopsis thaliana as a model system, my laboratory studies the mechanisms of plant defense against microbial pathogens. We focus on a specific response known as systemic acquired resistance (SAR). SAR, which can be induced by a local infection, provides the plants with long lasting, systemic resistance against a broad spectrum of pathogens. Salicylic acid (SA; an active ingredient of aspirin) has been found to be the endogenous signal of SAR. Using a genetic approach, our laboratory identified genes involved in the regulation of SAR. Molecular and genetic analyses are being carried out to understand the gene function and to elucidate the SAR signaling pathway. These SAR-regulating genes are also favorite targets for molecular engineering of disease-resistance crops.
Areas of Interest:
signaling transduction mechanisms
regulation of gene expression
Representative Publications (More Publications) (search)
Wang, W., Barnaby, J. Y., Tada, Y., Li, H., Tör, M., Caldelari, D., Lee, D.-u. Fu, X.-D. and Dong, X.,Timing of plant immune responses by a central circadian regulator, Nature, vol. 470 (2011), pp. 110–114 .
Wang, S., Durrant, W. E., Song, J., Spivey, N. W., and Dong X., The Arabidopsis BRCA2 and RAD51 proteins are specifically involved in defense gene transcription during plant immune responses., Proc. Natl. Acad. Sci. USA (2010) [doi] .
SH Spoel, Z Mou, Y Tada, NW Spivey, P Genschik, X Dong, Proteasome-mediated turnover of the transcription coactivator NPR1 plays dual roles in regulating plant immunity., Cell, vol. 137 (May, 2009), pp. 860-72 [abs].
Tada, Y., Spoel, S. H., Pajerowska-Mukhtar, K., Mou Z., Song, J., Dong, X., Plant Immunity Requires Conformational Changes of NPR1 via S-Nitrosylation and Thioredoxins, Science (2008) [8he5p3s6CA6g&keytype=ref&siteid=sci] [abs].
Dong, W., Weaver, N.D., Kesarwani, M., Dong, X., Induction of Protein Secretory Pathway Is Required for Systemic Acquired Resistance, Science, vol. 308 (2005), pp. 1036-1040 .
Mou, Z. Fan, W., and Dong, X., Inducers of plant systemic acquired resistance regulate NPR1 function through redox changes., Cell, vol. 113 (2003), pp. 935 .
Durrant, W. E., and Dong, X., Systemic acquired resistance, Annual Review of Phytopathology, vol. 42 (2004), pp. 185-209 .
Li, X., Zhang, Y., Clarke, J.D., Li, Y., and Dong, X, Identification and cloning of a negative regulator of systemic acquired resistance, SNI1, through a screen for suppressors of npr1-1, Cell, vol. 98 (1999), pp. 329 .
Kinkema, M., Fan, W., and Dong, X., Nuclear localization of NPR1 is required for activation of PR gene expression, Plant Cell, vol. 12 (2000), pp. 2339-2350 .
Zhang, Y., Fan, W., Kinkema, M., Li, Xin, and Dong, X, Interaction of NPR1 with basic leucine zipper protein transcription factors that bind sequences required for salicylic acid induction of the PR-1 gene., Proc. Natl. Acad. Sci. USA, vol. 96 (1999), pp. 6523 .
Clarke, J.D., Volko, S.M., Ledford, H., Ausubel, F.M., and Dong, X., Roles of salicylic acid, jasmonic acid, and ethylene in cpr-induces resistance in Arabidopsis, Plant Cell, vol. 12 (2000), pp. 2175-2190 .
Cao, H., X. Li, and X. Dong, Generation of broad-spectrum disease resistance by overexpression of an essential regulatory gene in systemic acquired resistance., Proc. Natl. Acad. Sci. USA, vol. 95 (1998), pp. 6531-6536 .
Cao, H., J. Glazebrook, J. D. Clarke, S. Volko, and X. Dong., The Arabidopsis NPR1 gene that controls systemic acquired resistance encodes a novel protein containing ankyrin repeats., Cell, vol. 88 (1997), pp. 57-63 .
Cao, H., S. A. Bowling, A. S. Gordon, and X. Dong, Characterization of an Arabidopsis mutant that is nonresponsive to inducers of systemic acquired resistance., Plant Cell, vol. 6 (1994), pp. 1583-1592 .
Durrant, W. E., Wang, S., Dong, X., Arabidopsis SNI1 and RAD51D regulate both gene transcription and DNA recombination during the defense response., PNAS USA, vol. 104 no. 10 (2007), pp. 4223-7 [abs].
D Wang, K Pajerowska-Mukhtar, AH Culler, X Dong, Salicylic acid inhibits pathogen growth in plants through repression of the auxin signaling pathway., Current biology : CB, England, vol. 17 no. 20 (October, 2007), pp. 1784-90 [abs].
Wang, D., Amornsiripanitch, N., Dong, X., A genomic approach to identify regulatory nodes in the transcriptional network of systemic acquired resistance in plants, PloS Pathogens, vol. 2 (2006), pp. 1042-1050 .
SH Spoel, JS Johnson, X Dong, Regulation of tradeoffs between plant defenses against pathogens with different lifestyles., Proceedings of the National Academy of Sciences of the United States of America, United States, vol. 104 no. 47 (November, 2007), pp. 18842-7 [abs].
A. Heidel, J. D. Clarke, J. Antonovics, and X. Dong, Fitness costs of mutants affecting the systemicacquired resistance pathway in Arabidopsis thaliana, Genetics, vol. 168 (2004), pp. 2197-2206 .